A research team developed a budget-friendly method for adapting confocal microscopes for Total Internal Reflection Fluorescence (#TIRF) microscopy. The paper presents “a simple and cost-effective method to build a #prism-based TIRF setup on a laser scanning confocal microscope. The setup is affordable, and users can use both #confocal and TIRF modes in the same setup with the same light source and optical components.” Learn more: https://ilphotonics.com/inexpensive-high-resolution-single-molecule-microscopy/