StructBiolCommunicationsStructures of Burkholderia pseudomallei IspF from the methylerythritol phosphate pathway were determined with five different sulfonamide ligands bound, aiding in the discovery of new IspF inhibitors #IspF #Lyases #BurkholderiaPseudomallei https://doi.org/10.1107/S2053230X25001414
Analysis of Burkholderia pseudomallei IspF in complex with sulfapyridine, sulfamonomethoxine, ethoxzolamide and acetazolamide
The co-crystal structures of five sulfonamide ligands bound to the active site of the IspF enzyme from B. psuedomallei are reported. The ligands include the drugs ethoxzolamide, acetazolamide, sulfapyridine and sulfamonomethoxine.