Thinking about #PlaceCells and the #Hippocampus, do you think results in rats (/rodents) generalise well to humans, and conversely?
Only few #neuroscience papers with multi animals/humans/ai methods.
Lab mice models methods are invasive/non-reversible surgeries, diet/drugs restrictions/overdose, optogenetics, etc. Then post recovery therapies, or even euthanized.
Human methods non-invasive in healthy human patients, or less invasive in few terminally ill human patients.
Yet still underrated this key question on theoretics methods comparison rationale in multi humans/animals/ai #neuroscienceresearch
1/2
a. Too much in a sentence ?
» Because the hypothalamus in humans and mice is structurally similar, these findings are also useful for studying human behavior «
https://doi.org/10.3389/fnagi.2022.867863
b. Recently listened a lecture from this cross-disciplinary researcher publishing multiple mice and humans research, yet not hippo, but amygdala.
Ivan E de Araujo
https://youtu.be/EBk3RlzOhHQ
https://doi.org/10.1016/j.cell.2024.07.019
2/2
• This cool research:
» Despite differences between the mouse and the human brain, a cross species approach remains justified by the preserved homology of mammalian neural circuits.
However, there are inevitable limitations associated with comparing data across species «
hippocampus but:
human fMRI BOLD
mouse optogenetics pyramidal cells
2 inference models
https://doi.org/10.1016/j.cell.2020.08.035
• This opinion:
What do grid cells contribute to place cell firing?
Online NOW: lecture I refereed in this thread, on doubly mice/human, plus cross-disciplinary research by Dr. Ivan de Araujo
El Duvelle Neuro
Teixi