New: #Video explains #brain scans of those who’ve had #SARS2 vs never #infected

People who had covid showed BRAIN SHRINKAGE - usually in the orbital frontal cortex & parahippocampal gyrus (#memory #smell)

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https://www.msn.com/en-us/health/medical/brain-shrinkage-linked-to-covid-19/vi-AA1wLy7H

MSN

##Brain scans of people who’ve had #SARS-CoV-2 show a pattern of brain shrinkage that is distinct from normal aging. The orbitofrontal cortex and parahippocampal gyrus are the regions most likely to be affected post-#infection.

The ORBITAL FRONTAL CORTEX generates much interest because of some of the roles it is speculated to play in higher-order cognition, such as #DecisionMaking . It connects other regions of the brain to the sensory regions, #memory, and #emotion centers. Notable in #covid infections, this part of the brain processes #taste and #smell perception.

Cognitive functions usually associated with the orbitofrontal cortex include:

- Affective responses (emotional reactions)
- Decision making
- Impulse control

Damage to the orbitofrontal cortex may cause changes in social #behavior (how you interact with others and situations), decision making, and #personality.

People with damage to the orbitofrontal cortex may show -

MORE:
- Aggression
- Childish conduct
- Disinhibition
- Apathy
- Risky behavior

and LESS:
- #Motivation
- #Empathy / concern and for others
- Impulse control

Damage to the orbitalfrontal cortex may alter how the body reacts to emotions, leading to impulsivity and bad judgment. For instance, when making a bold decision, healthy patients exhibit physical symptoms of worry, such as sweaty palms. Patients with injury to the orbitofrontal cortex, however, did not.

Studies show that the orbitalfrontal cortex aids in forecasting decisions based on experience. If this part of the brain is damaged, people may make bad choices even though they are aware of the consequences.

ON THE BRIGHT SIDE, some people find that the changes in their brain make them feel happier, unnhibited, less prone to worry, and more animated.

https://practicalpie.com/orbitofrontal-cortex/

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Orbitofrontal Cortex

Despite being a poorly understood brain region, the orbitofrontal cortex (OFC) generates much interest because of some of the roles it is speculated to

Practical Psychology

The parahippocampal gyrus adds context to #memory and helps determine if a memory is real/fantasy

Important in navigation

Damage associated w schizophrenia https://pubmed.ncbi.nlm.nih.gov/2241505/

Atrophy linked to Alzheimer's https://pubmed.ncbi.nlm.nih.gov/10911879/
https://www.sciencedirect.com/science/article/abs/pii/S030645220800465X

The parahippocampal gyrus is one of the #brain areas found to shrink following #covid infection. More detail in this thread.

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The hippocampus and parahippocampus in schizophrenia, suicide, and control brains - PubMed

Recent postmortem studies in schizophrenia have shown abnormalities in medial temporal lobe structures, including the hippocampus and parahippocampus. We tried to replicate previous studies and to explore the specificity of this finding to schizophrenia. The anterior hippocampus and parahippocampal …

PubMed

BRAIN SHRINKAGE found after covid infection. Participants had brain scans prior to the pandemic as part of an unrelated study. Those who had been infected with #SARS2 showed a distinctive pattern of shrinkage on their scan results.

The orbitalfrontal cortex & parahippocampal were diminished, shrunk, in people who had experienced a #covid infection, compared to their pre-pandemic #brain scan. Harm to these areas is associated with:

⬇️ empathy
⬆️ aggression
⬆️ risky behavior
⬆️ Alzheimer’s
⬆️ schizophrenia
⬆️ memory issues
⬇️ navigation skill
⬇️ smell/taste acuity

🧵⬆️ more detail in this thread

Video explainer: https://cdn.jwplayer.com/videos/iSQdBk4P-SEwM0BSG.mp4

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