At last, we're able to share our latest work on #plant #immune system #pangenomes, focusing on #NLR genes in #arabidopsis
"Pangenomic context reveals the extent of intraspecific plant NLR evolution"
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https://biorxiv.org/cgi/content/short/2024.09.02.610789v1
#plantscience #plants #genomics #plant_pathogens #pathogens #coevolution
We exhaustively annotated all intact and degraded NLRs within complete genomes, using long read RNAseq and pangenome-wide TE annotation. We use pangenome graphs to explore the diversity of NLRs across accessions, and to define regions containing NLRs in a principled way.
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Our main finding is that many uncorrelated mutational processes create NLR diversity, and that there is no single metric that captures on its own the true extent of NLR structural and sequence variation. We also show that NLRs themselves are drivers of elevated pangenome complexity, rather than mere passengers on diverse regions.
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K. D. Murray
Philipp Bayer