michael

13-JUN-2024
Developing a system to study proteins without fixed structures
Researchers propose a novel pipeline that makes the analysis of intrinsically disordered proteins much faster and more convenient

I do love #IntrinsicallyDisorderedProteins but pinning them down to do a crystal structure is kind of against the spirit? NMR structures giving dynamic representations have served the field well

https://www.eurekalert.org/news-releases/1048185 #science #proteins #structuralBiology #IntrinsicDisorder

Developing a system to study proteins without fixed structures

Intrinsically disordered proteins (IDPs) can dynamically change their conformations depending on their external environment and can, therefore, bind to different compounds. However, they are difficult to analyze. Now, Tokyo Tech researchers have addressed this issue with a novel pipeline that enables a rapid crystal structure analysis of IDPs via a cell-free protein crystallization technique.

EurekAlert!
Jun 14, 2024 at 3:38pmWeb
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@proseandpassion

at one point, after the first ribosome crystal structures were published, I thought that was it. Now we know, game over.

But of course it's a dynamic system. One of the leaders in the field was nothing if not re-energized, about getting more structures, but representative of different states, like frames from a movie.