Pharmacogenetics Applied to the Treatment of Psychiatric Illness |
Fralin Biomedical Research Institute
Presentation by David Oslin, M.D., U Penn.
To: All prescribers of any type of Rx drug
Please watch. This is important.
-- signed, mother of a child who had neuroleptic malignant syndrome from Reglan / metoclopramide
https://www.youtube.com/live/nl4v2IDSHp8?si=C2PxyUS-S9wHbw4k
#medicine #MedMastodon #tootRx #pharmacology #Pharmacogenetics #pharmacy
It's interesting that cannabis users were included in the study since some of the terpenes present in cannabis might be inducers of CYP3A5* (CYP3A5 is induced by phenobarbital**). It did not seem to affect the results.
* https://doi.org/10.1016/0006-2952(88)90585-0
** https://doi.org/10.1006/abbi.2000.1697
paywalled, referenced by
https://www.jbc.org/article/S0021-9258(20)72880-2/pdf
VIPs: Very Important Pharmacogenes
https://www.pharmgkb.org/vips
"The PharmGKB is a pharmacogenomics knowledge resource that encompasses clinical information including clinical guidelines and drug labels, potentially clinically actionable gene-drug associations and genotype-phenotype relationships."
https://www.pharmgkb.org/about
#pharmacogenomics #pharmacogenetics #pharmacy #pharmacology #genetics #genomics #DrugMetabolism
#medicine
Rhyothemis