Ron Beavis ❌

FCAR:p may be found in the monocyte lineage: a type I membrane protein with 2 extracellular Immunoglobulin-like folds. Signal peptide: (1-21); extracellular region: (22-227); TM domain (228-246); intracellular S-phospho-IDR (247-287); N79, N141, N186+glycosyl. The soluble form in urine has no signals cward of R230.

Human cluster of differentiation member 89 (#CD89:p/#FCAR:p)―HPA mRNA tissue + cell type distributions & GPMDB protein tissue + cell type tabbulations. #proteomics #sources_sinks

Feb 28, 2024 at 12:51pmWeb
Show threadRon Beavis ❌Feb 28, 2024
The coverage diagrams for "urine" vs "monocyte" demonstrate the loss of the TM & intracellular regions in the soluble form. In order for the membrane form to function (binding IgA), it must bind to one of the Fc-gamma receptors, e.g. CD32 or CD64.
Show threadRon Beavis ❌Feb 28, 2024
The gene for this protein is part of the human chromosome 19 Leukocyte Receptor Complex, which means there are many haplotypes associated with the sequence & there is significant variability between species, e.g., rats have this gene while mice do not.
https://vega.archive.ensembl.org/info/data/LRC_Homo_sapiens.html
Human Chr 19 LRC region haplotypes