Jochen FrommExtrachromosomal #DNA in form of tiny DNA circles could be key drivers of #cancer. It looks strangely similar to the DNA of most bacteria which is contained in single circular molecules, the bacterial chromosome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10338009/
This recent paper is unfortunately behind a paywall. It is named "Extrachromosomal DNA in cancer"
https://www.nature.com/articles/s41568-024-00669-8
This article is a bit more accessible. After stem cells #ecDNA is the new hope of cancer researchers
https://www.the-scientist.com/cancer-may-be-driven-by-dna-outside-of-chromosomes-68590
Extrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications
Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA, including microscopic and sequencing approaches, has greatly enhanced our knowledge ...