David SchoppikAug 31, 2023
Mubarak Syed kicking off the #pbsscb grounding us in the land and the history and the rich diversity of the Pueblo of Sandia. https://www.pueblobrainscience.org absolutely tremendous outreach efforts bringing in and supporting tomorrow’s scientists.
Pueblo Brain Science

Hola, I am Syed (FlyGuy), a junior faculty at the University of New Mexico studying neural development in fruit flies https://www.neuraldiversity.org/ Other than research, I am committed to training and mentoring next-generation neuroscientists. At UNM, I have started an ambitious program, "Pueblo

Show threadDavid SchoppikAug 31, 2023

Jim Truman leads with #metamorphosis of the #Drosophila mushroom body (a locus of memory). He's walking us through a most beautiful piece of work. Special shout-out to the foresight it took to begin this work before there was a #connectome available so as to inform ongoing work.

tl;dr the molecular events that shape larval development can fade, allowing trans-differentiation of neurons (a shift from one brain area to another).

Shout-outs to @scottishwaddell

https://elifesciences.org/articles/80594
#pbsscb

Metamorphosis of memory circuits in Drosophila reveals a strategy for evolving a larval brain

The mushroom body neuropils of the larval brain have regions that share neurons and functions with the adult and larval-specific regions built with 'doomed' neurons or cells that trans-differentiate for temporary larval function before assuming their adult phenotypes at metamorphosis.

eLife
Show threadDavid SchoppikAug 31, 2023

Up next with Alex Kolodkin from Johns Hopkins on the development, wiring and function of direction-selective circuits in the mammalian visual system.

How do you put together a direction-selective brain circuit, in this case for stabilizing the image on the retina.

Relevant paper: https://www.sciencedirect.com/science/article/pii/S0960982222012131

#pbsscb

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