Martin Michaelis (he/him)

The complex issues associated with #Cancer #Screening. The benefits appear obvious, but there is a cancer risk from radiation during follow-up diagnostics in healthy individuals. Moreover, overdiagnosis and overtreatment can cause harm. 1/4

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2808653

Need for RCTs for Cancer Screening Blood Tests

In recent years, blood tests that look for circulating tumor DNA and biomarkers (termed liquid biopsies) have been developed. As Carr and Welch describe in this issue of JAMA Internal Medicine,1 these tests are being explored for diagnosis of suspected cancer, cancer surveillance after treatment,...

Aug 29, 2023 at 6:57amWeb
Show threadMartin Michaelis (he/him)Aug 29, 2023

Evidence that #LiquidBiopsies are promoted but not rigorously tested: "Circulating tumor DNA tests are being promoted for multiple indications. Numerous studies are ongoing, but randomized clinical trials of their effect on patient-centered outcomes are rare." 2/4

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2808647

Assessing the Clinical Utility of Liquid Biopsies

This review assesses 5 clinical indications for molecular-based tests to detect and quantify tumor DNA circulating in the bloodstream among patients with suspected cancer or recurrence.