Naturally occurring highly pathogenic #avian #influenza virus #H5N1 clade 2.3.4.4b #infection in three domestic #cats in North #America during 2023, J Comp Pathol.: https://doi.org/10.1016/j.jcpa.2023.07.001 #epizootic #panzootic #HPAI #mammals #pandemic #zoonoses #research
''#Necropsy consistently revealed pulmonary #congestion and #oedema, and cerebrocortical malacia with #haemorrhage was also seen in the cat that survived for 10 days. On #histology, all cats had necrotizing #encephalitis and interstitial #pneumonia with pulmonary congestion, oedema, #vasculitis and vascular #thrombosis. One cat also had microscopic multifocal necrosis in the #liver, #pancreas and an adrenal gland.''
{Formalin-fixed samples from brain of a HPAI H5N1 infected domestic cat}
''To the authors' knowledge, this #report is novel in that it describes a domestic #cat with HPAI #H5N1 #encephalitis dying 10 days after disease onset and with extensive malacic lesions (case 2). This report expands our knowledge of the range of lesions of HPAI H5N1 infection in domestic cats and supports findings that endothelial damage, vasculitis and vascular thrombosis are also important features of its pathogenesis.''