Journal of Cell ScienceRaj Kumar Sadhu, Aleš Iglič and Nir Gov review theoretical works demonstrating that curved membrane-bound protein complexes recruit cytoskeletal components, which together with the membrane, self-organise to form lamellipodia.
A minimal cell model for lamellipodia-based cellular dynamics and migration
Summary: We review theoretical works, demonstrating that curved membrane-bound protein complexes that recruit the protrusive forces of the cytoskeleton self-organize the cytoskeleton and the membrane to form lamellipodia.