Antitumor cell activity in glioblastoma regulated by inhibiting triggering receptor expressed on myeloid cells 2

While the importance of the triggering receptor expressed on myeloid cells 2 (TREM2) is known in brain microglial function during neurodegenerative diseases, the function of the TREM2 cell receptor/protein is unknown in glioblastoma tumors. In a new report in Science Advances, Rui Sun, and a research team in the departments of neurosurgery, pathology, anesthesiology and developmental biology at the Washington University School of Medicine, in the U.S., found the cell receptor to be highly expressed in myeloid subsets including macrophages and microglia, by using examples of human and mouse glioblastoma tumors.