Thiago Carvalho

'Our studies demonstrate that in vivo trans PD-L1/CD80 interactions do exist between T and tumor cells, and in vivo blockade of trans PD-L1/CD80 interactions or general PD-L1/CD80 interactions augment tumor immunity via expansion of IFN-γ-producing CD8+T cells and NOS2+macrophages in the tumor tissues.'

#immunology #immunooncology #immunotherapy #checkpointinhibitors

https://www.pnas.org/doi/10.1073/pnas.2205085120

Apr 24, 2023 at 10:18amWeb
Show threadhalama_immunoApr 26, 2023
@cyrilpedia Their observations show no change in the percentage of total #tumor associated #macrophages (TAMs) in the tumor tissue but a markedly increased percentage of NOS2+TAMs with no significant changes in arginase I expression...raising the question, which cell type would be the corresponding human counterpart? Macrophage or #monocyte ?