Christine Moissl-EichingerMar 12, 2023
Necrotizing enterocolitis (#NEC) is a devastating disease, affecting up to 11% of all very-low birthweight (<1500g) infants.
In our newest paper
@Naturecomms
we look at NEC prophylaxis regimens in clinics that are highly successful in preventing NEC (average NEC rate: 2.9%).
Show threadChristine Moissl-EichingerMar 12, 2023
We performed a detailed longitudinal #microbiome analysis (16S and metagenomics), combined with #metabolomics, to assess the effect of the three major factors - antibiotics, #probiotics, feeding - on presence of virulence factors, antibiotic resistances, and microbiome function.
Show threadChristine Moissl-EichingerMar 12, 2023
We found that protocols including the probiotic #Bifidobacterium longum subsp. infantis lead to an earlier maturation of the gastrointestinal tract, better human milk oligosaccharides (#HMOs) digestion, and a lower presence of antibiotic resistance genes.
Show threadChristine Moissl-Eichinger
However, the beneficial effects of Bifidobacterium strongly depends on the simultaneous feeding with HMOs, which are usually not (much) included in formula milk. So: mother's milk is the key!
Mar 12, 2023 at 2:23pmWeb
Show threadChristine Moissl-EichingerMar 12, 2023
Further improvements of current protocols, e.g. by using a combination of Bifidobacterium probiotic and human milk feeding could lower NEC incidence even further, hopefully saving many preterm babies' lives.
Show threadChristine Moissl-EichingerMar 12, 2023
👉https://nature.com/articles/s41467-023-36825-1
Amazing teamwork with e.g. @lindsayhall and brilliant work by #ECR first-author Charlotte Neumann.
Show threadChristine Moissl-EichingerMar 12, 2023
This work was supported by
@fwf, @MedUniGraz and DP_iDP.
Thank you!!