Biology OpenIn this Research Article, Michael Martinez, David Matus and colleagues re-examine the relationship between EGL-43 and LIN-12. Using a dual depletion approach, they show that LIN-12 is not required for #proliferation of the C. elegans anchor #cell following EGL-43 loss:
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Reevaluating the relationship between EGL-43 (EVI1) and LIN-12 (Notch) during C. elegans anchor cell invasion
Summary: Using a dual depletion approach, i.e., combining auxin-inducible degradation with RNAi, we show that LIN-12 is not required for proliferation of the C. elegans anchor cell following EGL-43 loss.