PLOS BiologyHow does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells
N6-methyladenosine (m6A) modification of RNA regulates normal and cancer biology, but how does it influence long noncoding RNAs (lncRNAs)? This study shows that the lncRNA HOTAIR represses or activates genes, depending on a single m6A modification, to affect breast cancer cell biology.