How the RNA vaccines activate the innate immune response & prime the adaptive response was one of the most frequent questions I got in 2020/2021.

"We discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the LNP components to their immunogenicity. A key message that is emerging from recent observations is that the LNP carrier acts as a powerful adjuvant for this novel vaccine platform"
#RNA #rnavaccines #Immunology #InnateImmunity

https://www.cell.com/immunity/fulltext/S1074-7613(22)00555-6