Lots of abstracts today! Here's our own abstract to #ASH22. One question in #ClonalHematopoiesis is whether cells with a #muation are more inflammatory at baseline or are simply more reactive to stimuli. Here, we use #CRISPR to knock-in the DNMT3A p.R882H hotspot mutation into hematopoietic stem cells and differentiate into monocytes. #Transcriptome profiling shows that the mutant cells have activated myeloid signatures even without stim: https://ash.confex.com/ash/2022/webprogram/Paper170803.html #Genomics #Hematology #RNAseq