smplReconfigured all my WM shortcuts to be based on the super key. Takes some getting used to no Alt+F1 and Alt+F4 to open and close a Terminal. They're now Super+t and Super+q.
I'm glad I did though, no more interfering with application shortcuts.
elithium crystal bullet+1 for the tux
imo, Super should be used for launching applications, Alt for window manipulation, Ctrl+Shift for in-app functions.
although i also use a combination of Alt+Super+arrows to resize windows...
@ioy
I was trying to finish Lion King in a patched DOSBox with savestates and my shortcuts kept interfering with the DOSBox defaults. Alt + F5 saves, in my WM it kills a window.
It happens regularly with software, so I decided it was time to isolate all my WM shortcuts by having them use super as a base (as no programs I've encountered do that). Now they will (hopefully) never interfere with a program again.
I made one exception. Alt + Tab is still Alt + Tab.
albi 
@smpl Yeah, I used to do that too. A few new distro installations later and I'm ok with whatever shortcuts are default. :D