Reprobio, biology reproductionhttps://link.springer.com/article/10.1007/s10815-026-03888-0
Enhorabuena a la próxima doctora Marta Reguera, que defenderá en breve su tesis "Aspectos Bioéticos de las Modificaciones Genéticas Mitocondriales en la Línea Germinal".
#MRT #MitochondrialDiseases #ART #Oocyte #Zygote
Current state of the art in the transmission of mitochondrial DNA pathogenic variants: reviewing preventive-therapeutic alternatives - Journal of Assisted Reproduction and Genetics
This review analyzes strategies to prevent or reduce the transmission of diseases caused by pathogenic variants in mitochondrial DNA (mtDNA). Among these, we will focus on prenatal screening, preimplantation genetic testing, gene-editing techniques, other molecular tools, and selected heterologous mitochondrial replacement techniques (MRTs), explaining their status and the uncertainties surrounding their clinical application. After this analysis and review, we recognise the limitations of the efficacy of prenatal and preimplantation genetic testing for mitochondrial DNA pathogenic variants, the legal constraints on gene editing, and the status of mitochondrial replacement techniques. MRTs are a safe and possibly more effective alternative for preventing diseases caused by mitochondrial DNA pathogenic variants.
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