Pesquisadores da Virginia Tech investigam por que alguns cânceres se tornam agressivos, analisando células com números anormais de cromossomos. O estudo identifica características associadas a tumores mais perigosos, sugerindo novos indicadores de gravidade da doença.
🔗 https://omniletters.com/virginia-tech-investiga-canceres-agressivos/
Repubblica.it: Guerra in Iran, le news di oggi. Esplosioni a Bandar Abbas. Teheran: “Non cederemo sull'uranio, sanzioni e Hormuz”
Si aggrava il bilancio dell’attacco israeliano a Gaza
Tony Blair attacks Starmer: “Aim for radical centrism”
Tony Blair’s disastrous departure – a “paper” of around 6,000 words released yesterday on the website of his think-tank amidst a civil war tearing apart the […]
Post Tony Blair attacks Starmer: «Aim for radical centre» first appeared on il manifesto.
Small and altered cells worsen cancer.
AGI - Some tumor cells with an abnormal number of chromosomes and smaller than expected sizes may be among the main factors that make certain tumors more aggressive and difficult to treat. This emerges from a study published in the Proceedings of the National Academy of Sciences (PNAS) and coordinated by Daniela Cimini of Virginia Tech, which analyzed the behavior of so-called tetraploid cells during tumor growth.
In healthy cells, the genetic heritage is normally composed of two copies of each chromosome, one inherited from each parent. However, sometimes during cell division, errors can occur that alter the number of chromosomes, favoring the onset of diseases such as cancer.
The Role of Tetraploid Cells
The researchers focused particularly on tetraploid cells, characterized by four complete copies of chromosomes. This condition is often associated with tumor progression and poorer prognoses for oncology patients.
Experimental Models and Results
To study the phenomenon, the research group induced diploid tumor cells to duplicate their chromosomes without completing cell division, thus obtaining tetraploid cells to use in experimental models. Comparing tumors originating from normal cells and tetraploid cells in mice, the scientists observed that, while decreasing numerically during tumor growth, tetraploid cells favored the rapid expansion of the tumor mass.
Interaction with Stromal Cells
According to the authors, the phenomenon is linked to the ability of these cells to recruit non-tumor stromal cells, connective tissue elements that provide structural support and support cancer progression.
An Unexpected Result
“The presence of even a small amount of tetraploid cells can promote the recruitment of non-cancerous cells that further promote tumor growth,” explains Megan Sweet, the first author of the study. However, during the research, a second unexpected result also emerged.
Smaller and More Aggressive Cells
When the researchers isolated several clones of human tetraploid tumor cells, they discovered that some were 25 to 30 percent smaller than expected. These smaller cells turned out to be the most aggressive.
Resistance and Tumor Growth
“Smaller cells grow faster, are more invasive, and better tolerate common anti-tumor drugs and stressful conditions,” observes Mat Bloomfield, co-author of the study. Experiments conducted in murine models confirmed that tumors consisting of smaller tetraploid cells tended to increase in size more quickly.
Different Types of Tumors
The same behavior was observed in both colon-rectal tumors and breast tumors.
Clinical Human Data
To verify whether the phenomenon was also present in humans, the research group analyzed data from the Cancer Genome Atlas, a large international archive of human tumor samples. The analysis showed that the presence of small-sized tetraploid cells was associated with poorer prognoses and reduced survival in several types of tumors.
Future Clinical Implications
“We already knew that tetraploidy can increase the tumor potential of cells,” explains Daniela Cimini. “Now we have discovered that including cell size also makes it possible to predict with greater accuracy the aggressiveness of the tumor.” According to the authors, the results could open up new perspectives in the development of prognostic biomarkers and targeted therapies against the most aggressive tumor cells. The next studies will be dedicated to deepening the biological mechanisms that connect cell size, chromosomal alterations, and cancer progression.
#DanielaCimini #VirginiaTech #MeganSweet #first #second #25to30percent #MatBloomfield
https://www.agi.it/cronaca/news/2026-05-27/cancro-cellule-tumore-37255588/
More than 60 percent of the United States is experiencing drought conditions, with more than 20 percent in an extreme drought. Andrew Ellis, a climatologist at Virginia Tech said the current conditions are among the worst in decades because the combination of intensity and aerial coverage is rare. He explained why, who is most impacted, and when we can expect relief.
Someone Appears To Be Stuck On The Jumbotron
https://web.brid.gy/r/https://defector.com/someone-appears-to-be-stuck-on-the-jumbotron
I can't claim to know the reason the BOV is pushing out Tim Sands, but it is not for the reason Kaine thinks. Sands was their perfect little puppet as evidenced by the BOV renewing his contract with a 200k raise before this. Something else is going on.
Sen. Tim Kaine suggests VT President Tim Sands may have been forced out | News/Talk 960-AM & FM-107.3 WFIR
https://wfirnews.com/news/sen-tim-kaine-suggests-vt-president-tim-sands-may-have-been-forced-out
Virginia Junior US Senator Tim Kaine says in a statement he is deeply troubled by the sudden departure of Virginia Tech President Tim Sands. During a press conference this morning, Kaine said this action has the earmarks of previous well-publicized efforts to oust Presidents at other Virginia publi
Hokie Time
The key to this game is going to be the interior run game of both teams. Tech has a history of getting gashed (although, the past 2 games they have done a remarkable job against 2 teams that run the ball quite well), and David WIlson is one of the top backs in the ACC, if not the country. If the Jackets can keep the Hokies less than 4.0 ypp on the ground, that means GT is in good shape. This means that not only must Tech contain Wilson and force predictable 3rd down situations, they must […]The Mars Volta – Frances the Mute
The Marts Volta - Frances the Mute Well, Tuesday, March 1st marks the release of one of MY most anticipated albums in quite some time. The Mars Volta will be putting out their 2nd full length album, Frances the Mute. I got a hold of a pre-release copy a few months ago, and despite the crappy quality of the version I found, it has been a steady member of my playlist lately. While only containing 5 tracks, the album spans almost 80 minutes, and does not disappoint if you’re a Mars Volta fan. […]https://danielandrews.com/2005/02/27/the-marts-volta-frances-the-mute/
iPhoto Books
I bought iLife 05 when it came out, and recently decided to give the ‘book feature’ a try. Basically, you can assemble a photo album, lay it out, and pick a theme for it, and they’ll print you a hard bound book for 29 bucks. Not a bad idea if you think about shipping costs, printing costs, etc. Each page after the original 20 they give you are a dollar each. So, you could end up spending a ton of cash on one of these things, but I decided to go with a conservative approach the first […]I bought iLife 05 when it came out, and recently decided to give the ‘book feature’ a try. Basically, you can assemble a photo album, lay it out, and pick a theme for it, and they’ll print you a hard bound book for 29 bucks. Not a bad idea if you think about shipping costs,…
Entanglement
December 30th, 2007 Between Myspace, Facebook, Twitter, Digg, Newsvine, Reddit, Pownce, Virb, Last.fm, Flickr, Tumblr, del. icio.us, a plethora of RSS feeds, email, IM … you get the picture … there’s a lot of social networking to be done! So much, in fact, that it becomes a chore just to keep up. I wanted to simplify my 8December 30th, 2007 Between Myspace, Facebook, Twitter, Digg, Newsvine, Reddit, Pownce, Virb, Last.fm, Flickr, Tumblr, del. icio.us, a plethora of RSS feeds, email, IM … you get the picture … there’s a lot of social networking to be done! So much, in fact, that it becomes a chore just to keep up. I wanted to…
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