Steve Dustcircle 🌹Why Do #Humans Have an #Appendix?
Long believed to be purely #vestigial, this troublesome #organ may play an important role in #gut and #immune function.
https://www.the-scientist.com/why-do-humans-have-an-appendix-72057
Journal of Exp BiolIn a fantastic series of experiments Keity Farfán-Pira & co have revealed that a tiny region of regulatory #DNA in the #vestigial gene governs whether insect wings are large or small and has played a key role in the evolution of insect #wing size
https://journals.biologists.com/jeb/article/226/10/jeb246008/310531
Photo credit: Sanjay Acharya, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0/deed.en via Wikimedia Commons.
To read the full research go to https://journals.biologists.com/jeb/article/226/10/jeb244692/310533
Crucial DNA at crux of insect wing size evolution
Closely related species are usually remarkably similar. But take a closer look, and subtle differences begin to emerge. Some may have longer limbs or wider bodies, and some fruit fly species have dinky wings while the wings of relatives are relatively large. ‘The diversity of wing size relative to whole body size is remarkable in insects, but it is currently unclear how wing-to-body proportions have changed through evolution’, says Marcos Nahmad from the Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN), Mexico. The proteins that control the development of wings are essentially the same across almost all fruit fly species, regardless of their physical differences, so how do these differences come about?Regions of DNA that control how the regulatory proteins are produced could tweak the way in which a limb develops. One member of the fruit fly family, Drosophila virilis, has petite wings compared with D. melanogaster and other species, which all have relatively large wings compared with their bodies. Knowing this, Nahmad and Timothy Evans (University of Arkansas, USA) wondered if a region of regulatory DNA found in the gene for a protein known as ‘vestigial’ – which controls wing growth – could be responsible for D. virilis’s smaller wings. If so, could D. melanogaster grow D. virilis-sized wings if Keity Farfán-Pira and Teresa Martinez-Cuevas (from Cinvestav-IPN) replaced the key section of D. melanogaster DNA with regulatory DNA from D. virilis?First, Farfán-Pira confirmed that D. virilis fruit flies develop smaller wings for their body size, and then she began the painstaking task of transferring a 1200 bp segment of D. virilis DNA from the section of DNA preceding the fly's vestigial gene into the correct place in the DNA of D. melanogaster eggs. In addition, the team added a gene that would turn the modified flies’ eyes fluorescent red, to be sure that the offspring produced by the D. melanogaster eggs carried the crucial D. virilis DNA.Eventually, after months of patience in the laboratory creating the genetically modified D. melanogaster eggs and then waiting for them to develop into flies, Farfán-Pira measured the wing and leg lengths of the insects and the team was astonished that the wings of the D. melanogaster carrying D. virilis DNA were far smaller for their body size than those of regular D. melanogaster. ‘We were shocked’, Nahmad admits. Inserting the D. virilis vestigial regulatory DNA sequence into the D. melanogaster vestigial gene was sufficient to make the flies’ wings smaller, like the daintier wings of D. virilis.But what does this discovery mean for how members of the insect family, ranging from flamboyant butterflies to stubby-winged bees, evolved such extensive wing differences given that they all use the same cellular machinery to coordinate wing development? The team suspects that the crucial section of vestigial gene DNA fine-tunes the distribution of the cell signalling proteins that regulate wing growth through the larvae's imaginal disk structure – which develops into the wings – to regulate wing size and allow the insect to develop either small or large wings, depending on their family history. The team concludes that some significant change in the key vestigial DNA segment occurred after the split between the D. melanogaster and D. virilis families, resulting in one branch of the family with relatively large wings while the other evolved their comparatively small wings, which persist to this day.
totally a botVestigial • Resonate
Listen to Vestigial on Resonate
Arcadely IRLSome crunchy gro-updates- enemies actually have a walk cycle, and their lil skulls just pop right off when u blow them up lol. (also so other things) #vestigial #vestigialgame #madewithunity #gamedev #bfig
Added more camera support so the enemies always stay in focus, which should also allow for more vertical gameplay (needs a little refinement tho!)! #vestigial #mechgame #madewithunity #indiedev
THE WAIT'S BEEN LONG, BUT-!!!!
Big ups- a player spawning sequence- (not heard, but here): a revamped audio setup, and numerous other things-------!! #vestigial #bfig #gamedev #madewithunity #MechGame
Big ups- a player spawning sequence- (not heard, but here): a revamped audio setup, and numerous other things-------!! #vestigial #bfig #gamedev #madewithunity #MechGame
Added a building you can destroy!
Also Cuh-RAZY fireballs, and finally, PLAYER ANIMATIONS??? in MY game?!? (It's more likely than you think)
#Vestigial #progress #gamedev #madewithunity
Testing Multi-displays and different screen ratios!! #Vestigial #gamedev #madewithunity #indiegamedev
#MechGame has a name! It's #Vestigial !!!!
Here's how far it's come-! enemy targeting, new player, AI and spawning and more under the hood-