Eight frontier LLMs, one RNA-seq dataset. We had them reproduce a published Candida auris analysis by using Orbit to drive Galaxy.
Six models independently replicated the original SCF1 downregulation finding—while their API costs varied 47× ($2.82–$131.83).
Read what we learned: https://galaxyproject.org/news/2026-06-09-llm-agents-reanalyze-rnaseq/
Eight LLMs, one RNA-seq dataset: what we learned controlling Galaxy from Orbit
We pointed eight frontier LLMs at the same Candida auris RNA-seq study and asked each to reanalyze it on Galaxy through Orbit. Six reproduced the headline result — and the failures taught us more than the successes.


