The EMBO JournalKeisuke Shigeta et al (Keio University School of Medicine) analyze #metabolic alterations leading to #chemoresistance in #urothelial cancer #bladdercancer: #IDH2 gain-of-function independent of #mutation is responsible for #HIF1α-dependent production of respective #gemcitabine and #CDDP competitors #dCTP and #NADPH