Lukas VFN 🇪🇺Jul 24, 2023

The prospect of a better treatment for Chagas disease and sleeping sickness https://blogs.biomedcentral.com/bugbitten/2023/07/21/the-prospect-of-a-better-treatment-for-chagas-disease-and-human-african-sleeping-sickness/

#Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections https://www.science.org/doi/10.1126/science.adh0614

"#NeglectedTropicalDiseases caused by #SingleCelled #parasites (#trypanosomatids) include #ChagasDisease, #SleepingSickness & #leishmaniasis. Progress in treatment of these #diseases had been slow, though large chemical library screens are now showing promising results."

BugBitten The prospect of a better treatment for Chagas disease and human African sleeping sickness

Tim DowningJun 28, 2023

#Aneuploidies are an ancestral feature of #trypanosomatids, and an ancient chromosome #duplication is maintained in extant species

João Luís Reis-Cunha et al
bioRxiv 2023.06.26.546280; doi: https://doi.org/10.1101/2023.06.26.546280

#leishmania #genome #genomics #aneuploidy

Lukas VFN 🇪🇺May 9, 2022

Parasite #GeneEditing technology for profiling drug-resistance mutations https://www.lifesci.dundee.ac.uk/news/2022/may/9/parasite-gene-editing-technology-profiling-drug-resistance-mutations

Oligo targeting for profiling drug resistance mutations in the parasitic #trypanosomatids: Simone Altmann et al. https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac319/6582176 #protists #parasites #trypanosoma

Parasite gene-editing technology for profiling drug-resistance mutations

A team from the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee has developed a new parasite gene-editing technology. This method, known as oligo-targeting, involves delivering short DNA fragments to parasites using a pulse of electricity. The DNA, including the desired edits, is then incorporated into the genomes of cells that are in the process of replicating their DNA. The approach is fast, simple, precise, and inexpensive.

School of Life Sciences