Still the worst devaluation of randomization I have ever come across. #stats #trialdesign #experimentaldesign #mumbojumbo

https://www.practicalradonc.org/article/S1879-8500(22)00384-8/fulltext This is an interesting paper which shows that dose adaptation should reduce bowel doses significantly. This is at once important and at the same time bring into question how we can design trials which actually test the hypothesis with endpoints that matter to the patient - toxicity and QoL @f2harrell @statsepi how should we design trials which allow us to bring this practice into the clinic ? #TrialDesign #RadOnc #Toxicity