trendlessTIL about Mastodon-Archive
https://github.com/kensanata/mastodon-archive
This tool enables you to make an archive of your statuses, your favourites, bookmarks and the media in both your statuses, your favourites and your bookmarks.
Bruce HamiltonHow much genetic function is required to avoid the worst phenotypes? For Tulp3, the answers may surprise you! New pre-print from my lab, led by postdoc Corinne McCoy, using an 8-part genotypic series in mice. #Tootorial https://www.biorxiv.org/content/10.1101/2025.04.25.650726v1 1/
Tulp3 quantitative alleles titrate requirements for viability, brain development, and kidney homeostasis but do not suppress Zfp423 mutations in mice.
Tubby-like protein 3 (TULP3) regulates receptor trafficking in primary cilia and antagonizes SHH signaling. Tulp3 knockout mice are embryonic lethal with developmental abnormalities in multiple organs, while tissue-specific knockouts and viable missense alleles cause polycystic kidney disease. Human patients with TULP3 mutations present with variable, but often multi-organ fibrotic disease. We previously showed that mouse and human Tulp3 expression is negatively regulated by ZNF423, which is required for SHH sensitivity in some progenitor cell models. The level of TULP3 function required to prevent mutant phenotypes has not been known. Here we report a Tulp3 quantitative allelic series, designed by targeting the polypyrimidine tract 5-prime to the splice acceptor of a critical exon, that shows distinct dose-response effects on viability, brain overgrowth, weight gain, and cystic kidney disease. We find limited evidence for genetic interaction with Zfp423 null or hypomorphic mutations. Together, these results establish an approach to developing quantitative allelic series by exon exclusion, rank-order dose-sensitivity of Tulp3 phenotypes, and model thresholds for TULP3 function to prevent severe outcomes. ### Competing Interest Statement The authors have declared no competing interest. National Institute of Neurological Disorders and Stroke, , R01 NS097534 National Cancer Institute, , T32 CA067754, P30 CA023100 National Institute of General Medical Sciences, , R25 GM083275 National Institute of Diabetes and Digestive and Kidney Diseases, , P30 DK063491
CapeTaunCiao persone che state subendo una scaterva di tag indesiderati dalla nuova ondata di bot. Non penso sia possibile bloccare i tag, ma quanto meno potete filtrare le notifiche in modo da non esserne sommers3.
Se dall'app base o dal sito aprite le notifiche, troverete questo menu impostazioni che vi permette di ACCETTARE (le notifiche arrivano) FILTRARE (finiscono in una casella a parte) o IGNORARE (non appaiono per nulla) a seconda di quanto vi fidate.
katch wreckwho called it #feditips and not a #tootorial jk
Cade the Cat#MastoHelp #Tootorial
Is there a way to have certain profiles' posts not show up on my home, but show up in one of my lists? I ask because I enjoy bot content, but lately bot content has been clogging up my home, and I kind of want to sequester it to a "just for when I want to see bot content" list rather than unfollow the bot accounts entirely.
I've tried filters, but not all of the bots label their content as bot-generated, so that doesn't seem to be doing the trick. And I can't figure out how to filter out posts from a specific domain, like botsin.space
Sharing posts from the 
mobile webUI to an external source is awesome: not only does it include the entire text from the post and the link, but also any alt text from the image(s) 👌
Vicomte Folmer af HelvedeIf you're using one of the 'Elephant' themes (☝️) on #ZeroesCA:
When on mobile, the bottom bar scrolls horizontally to provide access to Local, Federated, Private Mentions, Bookmarks, Favourites, Settings, and … (About)
Rafael Wagner@samkuhn Its actually really cool, I'll make a #Tootorial about it soon.