Turns out RNA can make a GNRA tetraloop-like motif out of almost anything! Like in these pentaloops, whose looped-out bases interact with proteins.

Read the preprint:
https://biorxiv.org/content/10.1101/2025.07.03.663028v1

#RNA #Structure #3D #GNRA #Tetraloop #Motif #Research #RNAprotein #Interactions

In the raiA ncRNA structure that we recently determined, we identified a junction strand (B) that mimics both the GAAA-tetraloop (A) AND the D-loop/T-loop interaction motif (C) - how cool is that?

Find out more:
https://doi.org/10.1016/j.jmb.2024.168833

#RNA #research #science #Structure #structuralbiology #cryoEM #junction #tetraloop #strand #motif #Dloop #Tloop #GAAA #GNRA #raiA