CavalliLabMar 20, 2023

Very interesting counteracting functions of SWI/SNF and NuRD complexes, countering versus favouring Polycomb-mediating repression at bivalent genes. On the other hand, SWI/SNF maintains high level of promoter-proximal Pol II, whereas NuRD rather increases its constant release into the gene body

The impact of #swisnf and NuRD inactivation on
gene expression is tightly coupled with levels of RNA
#polymerase II occupancy at #promoters
https://genome.cshlp.org/cgi/content/long/gr.277089.122v1
@genomeresearch

The impact of SWI/SNF and NuRD inactivation on gene expression is tightly coupled with levels of RNA polymerase II occupancy at promoters

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

CavalliLabJan 23, 2023
A #oncohistone, #Polycomb #SWISNF interplay provides a possible avenue for treatment of #pediatric gliomas: #BAF Complex Maintains #Glioma Stem Cells in Pediatric #H3K27M #Glioma - https://doi.org/10.1158/2159-8290.CD-21-1491 @CD_AACR
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

The BAF complex, in particular ATPase subunit SMARCA4/BRG1, is critical for maintaining pediatric H3K27M-glioma cells in an oncogenic progenitor state, and pharmacologic inhibition is a potential therapeutic avenue for these highly aggressive tumors.

American Association for Cancer Research
Nicholas FlemingNov 13, 2022
First post: #cancerresearch #cancer #immunotherapy #immunooncology #oncology #cancergenomics #macrophage #tcell #dendriticcell #oncogene #cytokine #generegulation #miRNA #snRNA #snoRNA #lncRNA #cancercell #swisnf #colorectalcancer #breastcancerresearch #melanomaresearch #headandneckcancerresearch #ovariancancerresearch #lungcancerresearch #Aotearoa #NewZealand