^ if this paper is of interest. There's a related preprint from van der Groot, Dal Peraro and D’Angelo labs:
This is cool. CryoEM showing COPI coat containing GOLPH3, together with functional data suggests the mechanism for cargo retention/transport.
The mechanistic basis of cargo selection during Golgi maturation
Taylor, Zubkov, Ciazynska et al.
James and Selena's paper is out in JCB!
We present a structural model of the interaction between TACC3 and ch-TOG. Then we discover Affimers that can inhibit this interaction. Expression of the Affimers in cells uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis.
Looks like cryo-ET studies of synapses are hot right now (pardon the pun). Another preprint, this time on dopaminergic terminals, looking at vesicle structures in situ.
and while we are at it, this other preprint uses cryo-ET on *native* synapses to look at vesicles in the terminal
https://www.biorxiv.org/content/10.1101/2024.04.01.587595v1
#structuralbiology #structbio #cellbiology
Wow! Preprint from the Rubinstein lab shows the structure of V-ATPase in synaptic vesicles. Synaptophysin is part of the V-ATPase!
hmmmm, the "exlusome"
#structbio #molecularcell #Science
From: @bioRxiv_cellbiol
https://botsin.space/@bioRxiv_cellbiol/109956833473897972
📰 "A special envelope separates extra-chromosomal from chromosomal DNA in the cytoplasm of mammalian cells" by 🔬 Schenkel, L., Wang, X., Le, N., Burger, M., Kroschewski, R. #bioRxiv #cellbiology http://biorxiv.org/cgi/content/short/2023.03.02.530628v1?rss=1
New package! MRCFile.jl is a #JuliaLang parser for the MRC file format commonly used to store data like that produced by electron microscopy. #StructBio https://github.com/sethaxen/MRCFile.jl
I wrote this package for a project during my PhD and just now got around to registering it. I don't work with MRC files anymore, so if you do and are interested in co-maintaining, let me know!
Stephen Royle
Royle Lab News
Dan Bose
cryo2go :unverified:
Seth Axen 🪓 
Andy Pandy