EMBL EventsMar 5, 2025

Are you ready for #EMBLEpitrans? Prepare to deep dive into advances in RNA modification functions, their key roles in gene expression, disease, and transformative therapies. Be part of the community🔬💡

📩 Submit your abstract by 5 August
🗓️ 28 – 30 October
📍 EMBL Heidelberg and Virtual
➡️ https://s.embl.org/etc25-01-ma

#EMBLEvents #geneexpression #RNAmodification #mRNA #RNA #transcriptome

The epitranscriptome

Science NewsApr 25, 2024
#RNAmodification is responsible for the disruption of #mitochondrial protein synthesis in #Alzheimers disease: #Methylation of #mRNA disturbs the production of ND5, a subunit of complex I of the respiratory chain / Impairment of the brain's energy supply
https://nachrichten.idw-online.de/2024/04/25/rna-modification-is-responsible-for-the-disruption-of-mitochondrial-protein-synthesis-in-alzheimer-s-disease
RNA modification is responsible for the disruption of mitochondrial protein synthesis in Alzheimer's disease

idw_onlineApr 25, 2024
#RNAmodification is responsible for the disruption of #mitochondrial protein synthesis in #Alzheimers disease: #Methylation of #mRNA disturbs the production of ND5, a subunit of complex I of the respiratory chain / Impairment of the brain's energy supply
https://nachrichten.idw-online.de/2024/04/25/rna-modification-is-responsible-for-the-disruption-of-mitochondrial-protein-synthesis-in-alzheimer-s-disease
RNA modification is responsible for the disruption of mitochondrial protein synthesis in Alzheimer's disease

Cosmin SaveanuJan 30, 2024

It's nice to see, from time to time, a negative result getting published. The title is quite clear (although m6A is not very abundant in 5' untranslated regions):

"N6-methyladenosine in 5′ UTR does not promote translation initiation"

pdf link:
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)01074-2.pdf

#ribosome #rnamodification

Gal Haimovich 😷🔬☣🏳️‍🌈🏳️‍⚧Jul 17, 2023

This is cool:
"Direct sequencing of total Saccharomyces cerevisiae tRNAs by LC–MS/MS"

#RNA #tRNA #MassSpec #RNAmodification
#yeast

https://rnajournal.cshlp.org/content/29/8/1201.full

Direct sequencing of total Saccharomyces cerevisiae tRNAs by LC–MS/MS

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

Gal Haimovich 😷🔬☣🏳️‍🌈🏳️‍⚧Jan 4, 2023

Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.

They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.

@MolecularCell

https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9

PLOS BiologyNov 29, 2022
How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells

N6-methyladenosine (m6A) modification of RNA regulates normal and cancer biology, but how does it influence long noncoding RNAs (lncRNAs)? This study shows that the lncRNA HOTAIR represses or activates genes, depending on a single m6A modification, to affect breast cancer cell biology.

PLOS BiologyNov 29, 2022
How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells

N6-methyladenosine (m6A) modification of RNA regulates normal and cancer biology, but how does it influence long noncoding RNAs (lncRNAs)? This study shows that the lncRNA HOTAIR represses or activates genes, depending on a single m6A modification, to affect breast cancer cell biology.

PLOS BiologyNov 29, 2022
How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells

N6-methyladenosine (m6A) modification of RNA regulates normal and cancer biology, but how does it influence long noncoding RNAs (lncRNAs)? This study shows that the lncRNA HOTAIR represses or activates genes, depending on a single m6A modification, to affect breast cancer cell biology.