#Radiochemistry: #OpenSource flow setup for rapid & efficient [18F]fluoride drying for #automation of #PET #tracer syntheses:
-several advantages over traditional azeotropic distillation
https://doi.org/10.1002/jlcr.4080
#DIYbio #chemistry #lab #instruments #FlowChemistry #fluorination
In this work, we introduce a low-cost open-source flow system that includes a dual syringe pump with implemented pressure sensor and back pressure regulator. The entire system can be built for around 500 €. Commercially available flow systems can be very expensive with equipment starting at, but often greatly exceeding, 10,000 €. This high price of entry makes such technology prohibitively expensive for many research groups. Such systems stand to benefit the emerging academic pharmaceutical field by providing the experience and availability of reliable and affordable solutions. To implement accessible flow chemistry at research facilities, the systems must be made affordable. In addition, space in research laboratories is usually limited and commercially available flow systems can be very bulky. Having a compact and individually adjustable system is thus beneficial, with 3D printing technology offering the solution. Our compact 3D-printed system meets the needs of many applications in flow chemistry research as well as educational requirements for universities. As a proof of concept, we conceptualized, developed, and tested a custom flow system that can be used to synthesize [18F]2-fluoro-2-desoxy-d-glucose ([18F]FDG), the most commonly used PET-tracer. This system was designed to perform the typical functions and operations required in radiotracer production i.e. radiofluorination, dilution, SPE-trapping, deprotection, and SPE-elution. With this proof-of-concept in hand, the system can be easily customized to produce other radiopharmaceuticals. Graphical Abstract
Good explainer on why the #ZNPP is much safer than #Chernobyl or #Fukushima from #radiochemistry expert Cheryl Rofer.
#Zaporizhzhia #Ukraine #Nuclear
https://nucleardiner.wordpress.com/2023/07/04/the-danger-at-zaporizhzhia-nuclear-power-plant/
Hi Mastodonians, MastoDons, & MastoDoñas!
I am an oncologist and scientist at the NCI developing #radiopharmaceuticals in the lab to help image and treat cancer.
My research sits at the interface of #oncology #chemistry #radiochemistry #DrugDevelopment #ClinicalTrials #nucmed #radonc.
Beyond the professional, I enjoy #audiobooks, #fitness, #coffee, and occasional #beer #homebrewing.
Looking to connect with and learn from diverse thinkers in oncology, medicine, and beyond.
Let's start with an #introduction
I'm Mike and during the day I deal with #radiochemistry #chemistry in PET research.
At night and on the weekends, I'm heavily involved with #magicthegathering as an aspiring competitive player and a Level 2 #JudgeAcademy #MagicJudge
If you've got questions about either, lemme know! I totally dig discussing either.
SFU Science
Bose-Einstein-Kondensat
Andrew Bennett
Freddy E Escorcia 
Mike of Magic and Chemistry