Industry ExaminerJan 28
#Amgen’s Dark Blue deal (up to $840m) is less about one preclinical asset and more about a trend: pharma is paying to remove proteins, not just block them. Feature: https://biotech.industryexaminer.com/amgen-dark-blue-protein-degrader-aml/ #Hematology #AML #Oncology #Biotech #Pharma #DrugDevelopment #ProteinDegradation #TechNews
Amgen’s $840m wager on Dark Blue shows why pharma keeps paying to make proteins disappear - Biotech Industry Examiner

On a cold Tuesday in early January, Amgen quietly made one of the more revealing oncology bets of the new year: it agreed to acquire Oxford-based Dark Blue

Biotech Industry Examiner
CSBJAug 30, 2025

🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.

🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling

Show threadStephan HackerAug 4, 2025

Excited that Christina Woo (Harvard University) will visit us for a @LED3hub Lecture.

Looking forward to hearing more about her group's exciting research in the fields of #ChemBio, #ChemicalProteomics, #Chemistry and #ProteinDegradation.

https://www.nature.com/articles/s41586-022-05333-5

The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron - Nature

C-terminal cyclic imides are physiological degrons that enable the ubiquitin E3 ligase adapter protein cereblon to target substrates for degradation.

Nature
Stephan HackerAug 4, 2025
Excited that Christina Woo (@thewoolab.bsky.social, @harvard.edu) will visit us for a @led3hub.bsky.social Lecture. Looking forward to hearing more about her group's exciting research in the fields of #ChemBio, #ChemicalProteomics, #ChemSky and #ProteinDegradation. www.nature.com/articles/s41...

RE: https://bsky.app/profile/did:plc:jnlt3o3km3ebst2vcigkwdch/post/3lvbicnjmyv2o
Cosmin SaveanuDec 17, 2023

Tagging of proteins for their inducible degradation is a great tool for the study of gene function. A systematic investigation of what sequence triggers protein degradation in #yeast is timely:

https://pubmed.ncbi.nlm.nih.gov/38102142/

#ubiquitin #proteindegradation #molecularbiology #genetics

Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons - PubMed

Selective protein degradation typically involves substrate recognition via short linear motifs known as degrons. Various degrons can be found at protein termini from bacteria to mammals. While N-degrons have been extensively studied, our understanding of C-degrons is still limited. Towards a compreh …

PubMed
Adam M GilbertJan 9, 2023
ASGPR-mediate clearance of PCSK9 via LYTACs - various flavors showing modular flexibility to yield degraders #proteindegradation #PFEColleague https://bit.ly/3ZoiBIR
Adam M GilbertJan 5, 2023
Dihydrouracil CRBN PROTAC ligands; better aqueous/base stability than IMiDs and eliminates a chiral center that easily racemizes. In NVS PROTAC patents since 2019 but nice to see in the published literature #proteindegradation #PFEColleague https://bit.ly/3ZeG7Iw
IMPJan 2, 2023
To degrade or not to degrade? That is the question answered by @haselbachlab in 2023's first video. Enjoy a mini lecture on #proteindegradation, #cryoEM, & #structuralbiology: 📺https://youtu.be/bU0UOJJBqH4
IMP Mini Lectures | David Haselbach: To degrade or not to degrade?

YouTube
Janet KumitaDec 20, 2022
Hello! I am an MRC CDA fellow in the Pharmacology department at the University of Cambridge. Me and my research group are fascinated by the molecular mechanisms that underlie protein self-assembly. We work on strategies to prevent amyloid formation and we are using engineered biomolecular condensates to gain insights into how Nature utilises phase separation to facilitate protein degradation. #neurodegeneration #BiomolecularCondensates #proteindegradation #introduction #Proteindesign
Adam M GilbertNov 29, 2022
New spin in heterobifunctional lysosomal degraders using integrin receptors for target internalization/lysosomal degradation #proteindegradation #PFEColleague https://bit.ly/3Xzj8XA