π§ New paper by Huang et al.: By using #pharmacological #fMRI and dynamic #connectome-based #PredictiveModeling, they show how #cortisol reshapes whole-brain #NetworkDynamics during emotional memory encoding. Trial-level analyses reveal distinct but increasingly integrated #arousal and #memory networks under #stress, supporting a hormonally driven "memory formation mode".
#CauliflowerMushroom - #SparassisCrispa.
One of my fave #edible & #medicinal #WildMushrooms. It's found in many places around the world, including forests on #VancouverIsland.
We #forage for these wild #mushrooms & use it in making some soups & stir fry dishes.
It's used often in #traditional #Chinese #medicine #TCM because it contains active #pharmacological ingredients. In order to study its medicinal value better, the genomic sequence of S. crispa was published in Oct 2018.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207663
Dry weight of the #basidiocarp was found to contain up to 43.6% #BetaGlucan, which was approved for the treatment of #cancer in #Japan & recommended for #COVID19 patients to overcome #inflammation.
Experiments suggest that S. crispa contains chemicals that may stimulate the #ImmuneSystem & has many #biological properties including: #AntiTumor, #antiviral activity (reverse transcriptase inhibitory activity), #neuroprotection, #cardioprotection, #AntiInflammation, #hyperlipidemia, #AntiDiabetic medication, #antimicrobial compounds, & methicillin resistant Staphylococcus aureus #MRSA.
#ForestForaging #MushroomsMedicine #FoodFromTheForest #WildFoods #VanIsle #Wsanec #Saanich #PacificNorthwest #Cascadia #PNW #MushroomsMonday #LookReadLearn #AsianMastodon
Sparassis crispa (Hanabiratake) is a widely used medicinal mushroom in traditional Chinese medicine because it contains materials with pharmacological activity. Here, we report its 39.0-Mb genome, encoding 13,157 predicted genes, obtained using next-generation ...
"Next Chapter in the #Legend of #silphion Preliminary Morphological, Chemical, Biological and #Pharmacological Evaluations, Initial Conservation #studies and Reassessment of the Regional #Extinction Event"
Silphion was an ancient medicinal gum-resin; most likely obtained from a Ferula species growing in the Cyrene region of Libya ca. 2500 years ago. Due to its therapeutic properties and culinary value, silphion became the main economic commodity of the Cyrene region. It is generally believed that the source of silphion became extinct in the first century AD. However, there are a few references in the literature about the cultivated silphion plant and its existence up to the fifth century. Recently, a rare and endemic Ferula species that produces a pleasant-smelling gum-resin was found in three locations near formerly Greek villages in Anatolia. Morphologic features of this species closely resemble silphion, as it appears in the numismatic figures of antique Cyrenaic coins, and conform to descriptions by ancient authors. Initial chemical and pharmacological investigations of this species have confirmed the medicinal and spice-like quality of its gum-resin supporting a connection with the long-lost silphion. A preliminary conservation study has been initiated at the growth site of this rare endemic Ferula species. The results of this study and their implications on the regional extinction event, and future development of this species will be discussed.
"These results suggest that the abundance of #polysulfides in #broccoli #sprouts contribute to their #health-promoting properties. Our findings have important #biological implications for the development of novel #pharmacological targets for the health-promoting effects of broccoli sprouts in humans."
https://www.sciencedirect.com/science/article/pii/S2213231723002768?via%3Dihub
A major #hydrogenbond network within #Angiotensin II #receptor 1 determines signaling towards #Gq #Gprotein or beta-#arrestin in response to balanced or biased receptor agonists
#CryoEM structural and functional data by Haitao Zhang and coworkers with implications for #pharmacological targeting to control #bloodpressure and confer heart protection
https://www.embopress.org
/doi/10.15252/embj.2022112940
(2/6)
"...painless #ConcentrationCamp for entire societies, so that people will in fact have their #liberties taken away from them, but will rather enjoy it, because they will be distracted from any desire to rebel by #propaganda or #brainwashing, or brainwashing enhanced by #pharmacological methods. And this seems to be the Final Revolution.β
We are always interested in students for bachelor and master theses. The topics range from #bioinformatics, #bioanalytic|s to medical #pharmacological topics. For example, we are investigating whether #CBD has a DNA damaging effect (DSB, DNA double strand break). We would be happy to find someone who wants to work with #brain #organoids.
#DSB #dnadamage #bachelorthesis #masterthesis #fedijob #organoid #biomedicine
Fabrizio Musacchio
Ms. Que Banh
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katch wreck
The EMBO Journal
HistoPol (#HP) π΄ πΊπΈ π΄
RoedigerRG