Cytochrome P450: The Key to Drug Metabolism and Mental Health - Rackenzik

Cytochrome P450 regulates drug metabolism, shaping psychiatric treatment with precision medicine and genetic insights for better care.

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๐Ÿ’‰ ๐Ÿ‘ฉโ€โš•๏ธ Scientists from our institution and AstraZeneca have developed a method to map the atomic-level structure of amorphous drugs, demonstrated on a GLP-1 receptor agonist candidate for diabetes and obesity treatment.

#AstraZeneca #DiabetesResearch #PharmaceuticalScience

Read more: https://go.epfl.ch/A1U-en

Cracking the code of amorphous drugs for diabetes treatment

Scientists at EPFL and AstraZeneca have developed a method to map the atomic-level structure of amorphous drugs, demonstrated on a GLP-1 receptor agonist candidate for diabetes and obesity treatment.

Excited to share our latest research published in Journal of Molecular Liquids! By using NOESY , we show that the conformation of bicalutamide transitions from "closed" to "open" as concentration decreases, which plays a crucial role in polymorph stability.

Read the full article here: https://doi.org/10.1016/j.molliq.2025.126896

#Bicalutamide #Polymorphism #PharmaceuticalScience #NMR #ConformationalChanges

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