A great work by Ruchao Peng et al. published in @sciencemagazine Science 388,eadq7597(2025).
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis.

https://www.science.org/doi/10.1126/science.adq7597
#influenza #nucleoprotein #filament
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#Analysis of #polyclonal and #monoclonal #antibody to the #influenza virus #nucleoprotein in different oligomeric states, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.12.612748v1

Our analysis suggests that linear NP epitopes paired with their corresponding characterized detection antibodies could aid in designing and improving #diagnostic technologies for influenza virus.

The #frequency & #function of #nucleoprotein-specific #CD8+ T cells are critical for heterosubtypic #immunity against #influenza virus infection, J Virol.: https://journals.asm.org/doi/abs/10.1128/jvi.00711-24?af=R

We demonstrate that both CTL frequency & function are crucial for providing heterosubtypic immunity to influenza by utilizing an Ad-viral vector expressing a CD8 epitope only to rule out the role of antibodies, single-cell RNA-seq analysis, as well as adoptive transfer experiments.

#Sialic #Acid #Receptor Specificity in #Mammary #Gland of Dairy #Cattle Infected with Highly Pathogenic Avian #Influenza A(#H5N1) Virus, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/7/24-0689_article

Mammary gland tissues co-stained with sialic acids and influenza A virus #nucleoprotein showed predominant co-localization with the virus and SA α2,3-gal. HPAI H5N1 exhibited epitheliotropism within the mammary gland, and we observed rare immunolabeling within macrophages.