We are excited to announce a new feature in nlmixr2: mceta for FOCEi. This is a hybrid approach combines Monte-Carlo sampling with the classical FOCEi algorithm bringing flexibility & robustness to nonlinear mixed-effects modeling in pharmacometrics. #nlmixr2 #rstats
New features in #nlmixr2 4.0, a #rstats package include a vere-style loading, importing models from older versions of nlmixr2 and Rstudio bug fixes. See https://blog.nlmixr2.org/blog/2025-08-29-nlmixr2-verse/

In this month's Blog, I discuss a new feature in the nlmixr2 ecosystem (in babelmixr2) -- translating and using nlmixr2 models in optimal design. They are fast and easy to use making this my go to tool when doing optimal design. #nlmixr2 #rstats

https://blog.nlmixr2.org/blog/2024-11-06-poped/

babelmixr2 and PopED | nlmixr2

nlmixr: open source nonlinear mixed-effects modeling for R.

nlmixr2

nlmixr2 and rxode2 3.0 is out. It is a major release since there are some backward-incompatible changes. #nlmixr2 #rxode2 #rstats

https://blog.nlmixr2.org/blog/2024-09-18-nlmixr2-3.0.0-release/

nlmixr2 3.0 | nlmixr2

nlmixr: open source nonlinear mixed-effects modeling for R.

nlmixr2

We have a new nlmixr2 blog entry courtesy of Hitesh Mistry and Nicola Melillo (@NicolaMelillo) detailing how to upscale nlmixr2 using AWS. This is helpful for long running SAEM models. In the future it may be even more interesting with other methods parallelized. (#nlmixr2 #rstats)

https://blog.nlmixr2.org/blog/2024-03-05-aws/

nlmixr2, tidyverse and RStudio on AWS | nlmixr2

nlmixr: open source nonlinear mixed-effects modeling for R.

nlmixr2

A new version of #nlmixr2 was released on CRAN today. I will talk about a few features in the future:

- More flexible mu referencing

- User defined functions can now be used with nlmixr2 and rxode2

- Event handling changes

- Many new estimation methods for population only fitting
I am very grateful for both the nlmixr2 team and the nlmixr2 users who have helped me get to this point in nlmixr2's development.

See the blog for more details about the release.

https://blog.nlmixr2.org/blog/2024-01-09-nlmixr2-2.1.0-release/

nlmixr2 2.1.0/ rxode2 2.1.1 | nlmixr2

nlmixr: open source nonlinear mixed-effects modeling for R.

nlmixr2

Our colleagues at LAP&P are hosting a target-mediated drug disposition #TMDD course using #nlmixr2 at #PAGE2023 in A Coruña, Spain!

This is your chance to see nlmixr2 put through its paces in real-world #pharmacometrics by a world-class consulting team.

https://lapp.nl/lapp-page-course/

LAP&P course; An interactive translational pharmacometric case study for an antibody exhibiting TMDD | LAPP

In this one-day course we will specifically discuss the importance of understanding the pharmacology of mAbs to make the right decisions in TMDD model development.

LAPP

@justinwilkins @damiacer

That's what I was thinking. I think #nlmixr2 would fit right in there. Do you know folks at Roche? We should approach them.

- It is also validated against the #nlmixr2 / #rxode2 model so you know if it is working immediately
Want a single language for a few pharmcometric applications? How about giving #babelmixr2, an extension of #nlmixr2 a try?