#job alert: junior/mid-career PI opportunities in cancer research @ Oxford university: https://www.ludwig.ox.ac.uk/news/vacancies-assistant-or-associate-professor-level-cancer-researchers
Areas we're looking for:
#epigenetics #chromatin #epitranscriptomics #RNA #myeloidCells #spatialTranscriptomics
Please boost for visibility! @academicchatter #hiring
CAR-T cells vs bispecific monoclonal antibodies in #myeloidcells
'A retrospective study of 73 TCR patients included in trials was conducted: 36 received CAR-T and 37 received BiAbs. CAR-T produced a higher overall response rate (ORR) than BiAbs (97.1% vs. 56.8%, P=0.002). After a median of follow-up of 18.7 months, no significant difference in progression-free survival (PFS) was observed between the CAR-T and BiAbs groups (16.6 vs. 10.8 months; P=0.090), whereas overall survival (OS) was significantly longer in the CAR-T than in the BiAbs group (49.2 vs. 22.6 months; P=0.021).'
#Immunology #Immunotherapy
https://www.sciencedirect.com/science/article/pii/S2473952924002945
"We showed that treatment with an agonist against the tumor necrosis factor (TNF) receptor superfamily member CD40 in combination with a soluble β-glucan (BG), which targets the C-type lectin receptor (CLR) Dectin-1, was sufficient to trigger productive immunosurveillance in ICB-resistant mouse models of pancreatic ductal adenocarcinoma."
#immunology #Immunotherapy #myeloidcells
https://www.science.org/doi/full/10.1126/sciimmunol.adj5097#tab-contributors
Referenced link: https://medicalxpress.com/news/2023-05-antitumor-cell-glioblastoma-inhibiting-triggering.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-05-antitumor-cell-glioblastoma-inhibiting-triggering.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1663178385076506624#m
RT by @physorg_com: Antitumor cell activity in #glioblastoma regulated by inhibiting triggering receptor expressed on #myeloidcells 2 @ScienceAdvances @CellCellPress https://www.mdpi.com/2072-6694/11/9/1315 https://medicalxpress.com/news/2023-05-antitumor-cell-glioblastoma-inhibiting-triggering.html
While the importance of the triggering receptor expressed on myeloid cells 2 (TREM2) is known in brain microglial function during neurodegenerative diseases, the function of the TREM2 cell receptor/protein is unknown in glioblastoma tumors. In a new report in Science Advances, Rui Sun, and a research team in the departments of neurosurgery, pathology, anesthesiology and developmental biology at the Washington University School of Medicine, in the U.S., found the cell receptor to be highly expressed in myeloid subsets including macrophages and microglia, by using examples of human and mouse glioblastoma tumors.
Cool paper dissecting the mechanism of action of #immunecheckpointblockade, anti-CTLA-4, and showing the important role of #myeloidcells #macrophages
"Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling"
#naturecancer #immunotherapy #immunecheckpointinhibitor #macrophages #IFNI
Yofe et al. demonstrate that FcγR engagement early after anti-CTLA-4 blockade induces a rapid remodeling of innate immunity and activation of type I interferon signaling, which are crucial for successful anti-CTLA-4 therapy.
#intro
Hi #sciencemastodon! I am a #postdoc in the Laboratory for Molecular and Cellular Therapy #VUB 🇧🇪 working on #cancerstemcells and #colorectalcancer trying to develop a new therapeutic approach using #myeloidcells 👩🏻🔬🔬 Hoping to connect with scientists all over the world and share about science!
#womeninSTEM
#Globalcitizen #Globalscientist
🇦🇷 / 🇮🇹 > 🇫🇷 > 🇧🇪
Benjamin S-B 
Thiago Carvalho
Phys.org
Judit Svensson Arvelund
Virginia Giolito