Giuseppe MichieliRandom #mutagenesis of #influenza #hemagglutinin identifies new sites which modulate its acid-stability and cleavability, https://etidiohnew.blogspot.com/2025/07/random-mutagenesis-of-influenza.html
Alexander J. Stein#CRISPR can improve disease resistance in #wheat by giving access to a broader range of solutions beyond random #mutagenesis or intraspecific variation. #Geneediting can unlock new ways to improve crops & speed up #plantbreeding for resistance to crop diseases: https://www.frontiersin.org/journals/genome-editing/articles/10.3389/fgeed.2025.1542487/
JIPBUsing the transposon-associated TnpB to improve the efficiency of #CRISPR/Cas-9 #gene editing may prove to be a valuable tool to improve #crop yield and quality of #medicinal #plants
https://doi.org/10.1111/jipb.13758
@wileyplantsci
#PlantScience #JIPB #Arabidopsis #mutagenesis #botany
https://doi.org/10.1111/jipb.13758
@wileyplantsci
#PlantScience #JIPB #Arabidopsis #mutagenesis #botany
Structural #determinants of #spike #infectivity in #bat #SARS-like #coronaviruses RsSHC014 and WIV1, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00342-24?af=R
Through #mutagenesis and cryo-EM analysis, we revealed that besides the structural variations, the 623 site in the SD2 region is another important structural determinant of spike infectivity.
Lukas VFN 🇪🇺Ancient #volcanoes poisoned #ferns for millions of years https://www.earth.com/news/ancient-volcanoes-chaos-poisoned-ferns-for-millions-of-years/
#Climate-forced Hg-remobilization associated with fern #mutagenesis in the aftermath of the end-#Triassic #extinction https://www.nature.com/articles/s41467-024-47922-0
"the initial volcanic eruptions caused a dramatic shift in the planet’s climate. However, the environmental consequences unfolded over millions of years. Mercury contamination lingered in the environment, poisoning ecosystems long after the immediate extinction event."
🍽️You'd be stressed too if you had 10 billion people coming for dinner...😳
Using #CRISPR for targeted #mutagenesis on important #crop species like broomcorn #millet may help meet the growing need for global #FoodSecurity.
https://doi.org/10.1111/jipb.13669
@wileyplantsci
#JIPB #PlantSci #botany
#Epistasis mediates the evolution of #receptor binding mode in recent #human #H3N2 #hemagglutinin, Nat Commun.: https://www.nature.com/articles/s41467-024-49487-4
Combinatorial #mutagenesis reveals that G186D and D190N, along with other natural mutations in recent H3N2 strains, alter compatibility with a common egg-adaptive mutation in seasonal influenza vaccines. Our findings elucidate role of epistasis in shaping recent evolution of human hemagglutinin & substantiate high evolvability of its receptor-binding mode.
Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin - Nature Communications
The receptor binding mode of recent human H3N2 hemagglutinin has evolved due to mutations G186D and D190N, which epistatically interact and co-emerged in clades 3C.2a1b.1a and 3C.2a1b.2a2.
AI6YR BenI am constantly amazed that the older folks around here aren't all dead of chemical-caused cancer, given how much Roundup and pesticides are applied to their yards. (These folks pay for monthly chemical dousing, even if there are NO PESTS to apply those chemicals too -- we call it the Visit From The Merchants Of Death). #chemicals #mutagenesis #pesticides
#Organic farming is dishonest when it comes to genetic engineering as it also uses #GMO varieties—namely those developed by #mutagenesis. Costs of #GMOs are driven by approval hurdles, not patents: https://www-topagrar-com.translate.goog/acker/news/prof-qaim-haelt-oekolandbau-fuer-unehrlich-20001615.html?_x_tr_sl=de&_x_tr_tl=en #biotech #patents (1/2)
CellBioNews#CRISPR/Cas9-mediated targeted #mutagenesis of #inulin #biosynthesis in rubber #dandelion.
https://phys.org/news/2024-02-crisprcas9-mutagenesis-inulin-biosynthesis-rubber.html
CRISPR/Cas9-mediated targeted mutagenesis of inulin biosynthesis in rubber dandelion
Researchers have leveraged the power of the CRISPR/Cas9 genome editing system to enhance natural rubber production in rubber dandelion (Taraxacum kok-saghyz). The CRISPR system's efficiency and precision offer a promising avenue to address challenges faced by the rubber industry.