Victoria Stuart 🇨🇦 🏳️⚧️Global genetic interaction map of human cell reveals conserved principles of genetic networks
https://www.biorxiv.org/content/10.1101/2025.06.30.662193v1?rss=1
#interactome #MolecularGenetics #genetics #FunctionalGenetics
The Talented Dr. Snyder. Massive biomolecular shifts occur in our 40s/60s
https://med.stanford.edu/news/all-news/2024/08/massive-biomolecular-shifts-occur-in-our-40s-and-60s--stanford-m.html
Nonlinear dynamics of multi-omics profiles in human aging
https://www.nature.com/articles/s43587-024-00692-2
https://news.ycombinator.com/item?id=44393547
#MolecularGenetics #aging #StanfordU #MikeSnyder #CellBiology
AlphaGenome: AI for better understanding the genome - Google DeepMind
https://deepmind.google/discover/blog/alphagenome-ai-for-better-understanding-the-genome
https://news.ycombinator.com/item?id=44387659
Comment: even in well-studied organisms (E. coli; yeast: Saccharomyces; minimal synthetic cells ...) the function of a staggering number of essential genes is unknown.
#AlphaGenome #DeepMind #MolecularGenetics #Genomics #FunctionalGenomics
[biological evolution] Whole-genome duplication drives long-term adaptation
https://www.sciencedaily.com/releases/2025/03/250326221649.htm
https://news.ycombinator.com/item?id=43515443
Genome duplication in a long-term multicellularity evolution experiment
https://www.nature.com/articles/s41586-025-08689-6
#yeast #MolecularBiology #evolution #genetics #MolecularGenetics #multicellularity #adaptation #genomics #GenomeDuplication #CellBiology
Molecular animations reveal DNA's unzipping mechanism: Implications for viral and cancer treatments
https://www.sciencedaily.com/releases/2025/03/250320144758.htm
https://le.ac.uk/news/2025/march/dna-helix-microscopy-cancer
* scientists captured 1st detailed 'molecular movie' showing DNA being unzipped at atomic level
* reveals how cells begin crucial process of copying their genetic material
Structural dynamics of DNA unwinding by a replicative helicase
https://www.nature.com/articles/s41586-025-08766-w#Sec25
#cancer #MolecularGenetics #StructuralBiology #DNAreplication #DNAhelicase
Breakthrough molecular movie reveals DNA's unzipping mechanism with implications for viral and cancer treatments
Scientists have captured the first detailed 'molecular movie' showing DNA being unzipped at the atomic level -- revealing how cells begin the crucial process of copying their genetic material.
Mitochondria as you’ve never seen them
https://www.nature.com/immersive/d41586-025-00269-y/index.html
https://news.ycombinator.com/item?id=42899168
Comments
me: former mitochondrial (mt) researcher, published
mt difficult to prepare/isolate intact/pure
extraordinary imagery shows why
Yet another "illustration" 😉 of crit imp. of fundamental research
https://www.niehs.nih.gov/research/atniehs/labs/gisbl/pi/mdnar
https://tools.niehs.nih.gov/polg/ --> mt. diseases ...
https://en.wikipedia.org/wiki/Mitochondrial_disease
#BasicScience #mitochondria #CellBiology #PolG #disease #BasicResearch #MolecularGenetics #PEO #mtDNA #NIEHS
Top 10 discoveries about ancient people from DNA in 2023
https://johnhawks.net/weblog/the-top-10-discoveries-about-ancient-people-from-dna-in-2023
https://news.ycombinator.com/item?id=42033913
#DNA #AncientDNA #MolecularGenetics #evolution #EvolutionaryGenetics #polymorphisms #SNPs #anthropology #history
Prevalence of Problematic Papers in Non-Coding RNA Research
https://www.biorxiv.org/content/10.1101/2024.08.28.607530v1?rss=1
* prevalence of problematic papers in field of non-coding RNA (ncRNA) research
* 1.79% retracted; 5.68% raised concerns on PubPeer
* unreliable papers widely disseminated
* hundreds of thousands citations
* significant threat to research integrity / public health
#biology #MolecularBiology #MolecularGenetics #PeerReview #PubPeer #AcademicPublishing #AcademicJournals #RNA #ncRNA #FraudulentScience #JunkScience
Nonlinear dynamics of multi-omics profiles during human aging
https://www.nature.com/articles/s43587-024-00692-2
* Stanford; Mike Snyder well-known
* aging a complex process associated w. nearly all diseases (aging-related diseases)
* understanding molecular changes underlying aging
* consistent nonlinear patterns in molecular markers of aging
* substantial dysregulation at two major periods occurring at ~44 & ~60 years chronological age
* distinct molecules, functional pathways
Nonlinear dynamics of multi-omics profiles during human aging - Nature Aging
Understanding the molecular changes underlying aging is important for developing biomarkers and healthy aging interventions. In this study, the authors used comprehensive multi-omics data to reveal nonlinear molecular profiles across chronological ages, highlighting two substantial variations observed around ages 40 and 60, which are linked to increased disease risks.
Holly#stem #Science #health #immunology #moleculargenetics #spiffy #Texas
THX 1 created. Only 1137 to go
Scientists create first mouse model with complete, functional human immune system
A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created a humanized mouse model with a human immune system and a human-like gut microbiome that is capable of mounting specific antibody responses.