Happy new year! Just repotted my Nicotiana benthamiana plants that I will use for #research next year! They are my most favorite root-harboring model organism 😁
What is your most favorite model organism?
#nicotiana #plantscience #modelorganism

"Today, that weed [Arabidopsis thaliana] is widely regarded as a botanical superstar. Arabidopsis has been the focus of some 100,000 research papers. Its seeds have flown around the Moon; it is the go-to plant for experiments on the International Space Station. And when the scientific community decided which plant should be the first to have its genome sequenced, Arabidopsis emerged as the winner."

https://knowablemagazine.org/content/article/living-world/2025/how-humble-weed-became-superstar-plant-science

#Plants #Genetics #Biology #ModelOrganism

How a humble weed became a superstar of biology

Arabidopsis thaliana was always an unlikely candidate for the limelight. But 25 years ago, the diminutive thale cress launched the botanical world into the molecular era.

Knowable Magazine | Annual Reviews

"Zebrafish exposed to light pollution at night showed signs of anxiety, such as swimming less and staying close to aquarium walls. The next generation of zebrafish also showed anxiety-related behaviors, even without direct exposure to the light, suggesting lasting effects across generations."

https://earthsky.org/earth/light-pollution-fish-next-generation/

#ALAN #LightPollution #ModelOrganism

Light pollution affects fish even into the next generation

EarthSky | Updates on your cosmos and world

There was someone, like 10 years ago set up a biotech in California that was focused on making known patient mutations in really simple, highly reproductive model organisms (yeast, fly, worm), and then testing a variety of compounds to see if they resulted in the rescue phenotype.

I know they concentrated on lipid processing mutations initially.

I was describing this to someone, and could not remember the name of the person or company.

#genomics #biotech #ModelOrganism

A French study in a #ModelOrganism found that:

1. Acute exposure to 500-lux artificial light at night alters the expression of #genes in retinal cells involved in signaling pathways linked to cellular stress and inflammation;

2. Chronic exposure to #ALAN causes changes in both scotopic and photopic retinal sensitivity; and

3. ALAN exposure "impairs visual function in the long term, linked to retinal degeneration "which can lead to #vision loss."

https://www.sciencedirect.com/science/article/abs/pii/S1769449323003060

New results in a mouse model "demonstrate the rapid and potent effects of [artificial light at night] on cerebrovascular networks, highlighting the importance of ALAN mitigation in the context of health and cerebrovascular disease."

https://www.cell.com/iscience/fulltext/S2589-0042(23)01073-8

#Neuroscience #Chronobiology #MouseModel #ModelOrganism #Cerebrovascular #ALAN

A new transparent #killifish line called klara, generated using #CRISPR/Cas9, can significantly simplify explorations of #development, #senescence, ageing and #regeneration. #ModelOrganism https://elifesciences.org/articles/81549?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Generation of a transparent killifish line through multiplex CRISPR/Cas9mediated gene inactivation

Using the short-lived turquoise killifish, a transparent in vivo reporter line named klara is established that will be a valuable tool to explore development, senescence, aging, and regeneration.

eLife
Researchers decode 95.6% of the genome of Nicotiana benthamiana

The plant Nicotiana benthamiana, from the Solanaceae family, is one of the most widely used experimental models in plant science. In 2020, a research group at Nagoya University in Japan reported that N. benthamiana could be grafted with plants from different families, demonstrating a rare ability that many researchers thought impossible.

Phys.org