CellBioNewsMay 7, 2024

Seeing is believing: Observation of #migrasomes.

#organelles

https://phys.org/news/2024-05-believing-migrasomes.html

Seeing is believing: Observation of migrasomes

Migrasomes, novel organelles first reported by Professor Li Yu' s team in 2015, are vesicular structures with diameters ranging from 0.5 to 3 micrometers that form on the retraction fibers at the rear of migrating cells. These structures contain various biomolecules such as proteins, nucleic acids, and lipids, along with numerous small vesicles, each approximately 50 nanometers in diameter.

Phys.org
Christian TidonaDec 22, 2022

Did you know that during #embryo development, migrating #monocytes deposit tracks of pro-angiogenic #migrasomes guiding the formation of blood vessels?

In this interesting manuscript published in Nature Cell Biology, researchers at Tsinghua University in Beijing studied this phenomenon in the chorioallantoic membrane of chick embryos: https://www.nature.com/articles/s41556-022-01026-3

This could have implications in organotypic #tissueengineering and provide new ways how to inhibit #angiogenesis in solid #tumors.

Monocytes deposit migrasomes to promote embryonic angiogenesis - Nature Cell Biology

Zhang et al. have data suggesting that, in the chicken embryo, monocytes foster a pro-angiogenic microenvironment in advance of angiogenesis by depositing migrasomes enriched in angiogenic factors.

Nature