MIT researchers invent new human brain model to enable disease research, drug discovery | MIT News

A new 3D human brain tissue platform developed by MIT researchers is the first to int…
#NewsBeep #News #Headlines #Alzheimer'sdisease #brainmodel #cerebrovasculature #dementia #extracellularmatrix(ECM) #Latvia #Li-HueiTsai #LV #microglia #MITKochInstitute #MITPicowerInstitute #MulticellularIntegratedBrains(miBrains) #neurons #personalizedmedicine #RobertLanger
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Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @PLOSBiology plos.io/49mmzcm
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What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @PLOSBiology https://plos.io/46cBaE4
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Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @PLOSBiology plos.io/49mmzcm