NIOO-KNAWOct 11, 2024
New publication: High-resolution #methylome analysis uncovers stress-responsive genomic hotspots and drought-sensitive #transposableelement superfamilies in the clonal Lombardy #poplar.
https://doi.org/10.1093/jxb/erae262
High-resolution methylome analysis uncovers stress-responsive genomic hotspots and drought-sensitive transposable element superfamilies in the clonal Lombardy poplar

In poplar, different abiotic and biotic stresses induce methylation changes in common labile genomic regions, while drought induces global CHH hypermethyla

OUP Academic
CellBioNewsSep 26, 2023

Study finds linkage between #DNA #methylome and #RNA #transcriptome in #Fe deficiency in #tomato roots

https://phys.org/news/2023-09-linkage-dna-methylome-rna-transcriptome.html

Study finds linkage between DNA methylome and RNA transcriptome in Fe deficiency in tomato roots

Tomato (Solanum lycopersicum), one of the most important horticultural crops, is rich in iron and vitamins. As an essential micro-element for plants, iron (Fe) deficiency not only restricts tomato growth, development and fruit quality, but also poses health risks to animals and humans, resulting in human nutritional disorder worldwide.

Phys.org
Haojia WuJan 12, 2023
A new paper used deep whole-genome bisulfite sequencing to create an atlas of the human methylome, which presents a fragment-level analysis across thousands of markers for 39 cell types sorted from 205 healthy tissue samples. By analyzing the atlas, the authors were able to identify methylation patterns that are retained since embryonic development, providing new insights into gene regulation and potential biomarkers for liquid biopsies.
#methylome #atlas
https://www.nature.com/articles/s41586-022-05580-6
A DNA methylation atlas of normal human cell types - Nature

We describe a human DNA methylome atlas based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis of cell-type-specific markers and providing an essential resource for studies of gene regulation and for deconvolution of cell mixtures and liquid biopsies.

Nature