darachmOh now this is fun
Nielsen etc did absolute-calibrated #proteome #transcriptome and #metabalome on yeast in chemostats (C-limited), so another dope data set for the #PieChart Theory of #MicrobialGrowth
Also estimating the % occupancy of individual #enzyme , that 35 or so are >90% used up for throughput, so maybe limiting metabolic chokepoints
Oh and tldr #amino-acids are super limiting so #aminoacidMetabolismRules
Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation - Nature Communications
Understanding how yeast organizes its functional proteome is a fundamental task in systems biology. Here, the authors conduct a multiomics analysis on yeast cells cultured with different growth rates, identifying a linear dependence of the functional proteome on the growth rate.