The circadian clock controls transcriptional and signalling networks across tissues to maintain homeostasis, with pathological consequences to its disruption. Kuo et al. review our understanding of circadian genetic and molecular mechanisms in health and disease, as well as emerging opportunities to probe and therapeutically target circadian regulation.
Peri-adolescence, the developmental window surrounding pubertal onset, is a critical period for the emergence and escalation of anxiety symptoms, making accurate assessment essential. While parent-reports are typically prioritized in childhood and youth self-reports in later adolescence, these perspectives often diverge during peri-adolescence, and such discrepancies are inconsistently linked to age. This study tested whether pubertal stage, rather than chronological age, accounts for differences between parent- and youth-reported anxiety, aiming to clarify how anxiety is experienced and perceived during this sensitive developmental transition. Two-hundred peri-adolescents (ages 10-13) and their parents completed clinical interviews, anxiety rating scales, and the Pubertal Development Scale. Mixed-effects models tested whether discrepancies varied as a function of pubertal stage, controlling for age. We also explored the utility of Principal Components Analysis (PCA) to extract shared variance across informants into a single multi-informant anxiety score. More advanced pubertal stage was associated with greater discrepancies in anxiety reports, driven by higher youth self-reports and stable parent ratings—especially among clinically anxious youth (n = 94). PCA identified a single cross-informant factor that captured shared variance and improved prediction of clinical severity and functioning. Puberty, rather than age, plays a key role in how caregivers and adolescents report on anxiety symptoms. These findings underscore the need to account for pubertal stage in peri-adolescent assessment and support the utility of dimensional, developmentally sensitive approaches for integrating multi-informant data.
Agenzia Nova: I fatti del giorno - Nord Africa (2)
15 mag 17:00 - (Agenzia Nova) - Libia-Malta: MedSky aumentera' i voli tra Tripoli e Malta da giugno - La compagnia aerea privata libica MedSky... (Res)
The events of the day - North Africa (2)
May 15 17:00 - (Agenzia Nova) - Libya-Malta: MedSky to increase flights between Tripoli and Malta from June - The private Libyan airline MedSky... (Res)
#NorthAfrica #AgenziaNova #Libya #MedSky #Tripoli #Malta #Libyan
The authors report surprising covariations between subthreshold activity of single V1 neurons and behavior, demonstrating that interactions between external sensory inputs and internal states are implemented by a nonlinear modulatory signal in V1.
The Africa Centres for Disease Control and Prevention (Africa CDC) is closely monitoring the confirmed Ebola Virus Disease outbreak in Ituri province, Democratic Republic of the Congo, and is working with national authorities and partners to support a rapid, coordinated response.
The Africa Centres for Disease Control and Prevention (Africa CDC) is closely monitoring the confirmed Ebola Virus Disease outbreak in Ituri province, Democratic Republic of the Congo. Africa CDC is working with national authorities and partners to support a rapid, coordinated response. Initial laboratory results from the Institut National de Recherche Biomédicale (INRB) have revealed the presence of the Ebola virus in 13 of 20 samples tested. The results suggest a non-Zaire ebolavirus strain. Sequencing is underway to further characterize this strain. Health authorities report around 246 suspected cases and 65 deaths, mainly in Mongwalu and Rwampara health zones. Four deaths have been reported among laboratory-confirmed cases. Suspected cases have also been reported in Bunia, pending confirmation. Africa CDC is concerned about the risk of further spread due to the urban context of Bunia and Rwampara, intense population movement, mining-related mobility in Mongwalu, insecurity in affected areas, gaps in contact listing, infection prevention and control challenges, and the proximity of affected areas to Uganda and South Sudan.
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