The final stage of my #conference tour is today in Amsterdam at the spring meeting of the #MedChem and #ChemBio division of #KNCV in Amsterdam #KNCVMCCB2026.
Looking forward to a full day of exciting Medicinal Chemistry and Chemical Biology #research
The meeting was just opened by Iwan de Esch and the president of the KNCV MCCB division, Ingrid Dijkgraaf.
Interesting talk by Clemens Richert at #Biochemistry2026. He talked about "Nucleoside Phosporamidates with Roles in Chemical Biology and Medicinal Chemistry".
#Virus #RNA #Nucleotides #Biochemistry #Chemistry #ChemBio #MedChem #MedicinalChemistry
CC: @gdch
Interesting talk by Peter Fodran from the University of Groningen at #Lunteren2026. He talked about his group's work on the efficient and #MedChem friendly synthesis of privileged scaffolds for drug discovery.
https://www.fodranlab.com/
#Chemistry #ChemBio #DrugDiscovery #Synthesis
A very good read about computational chemistry and how it helps in drug discovery, and more importantly, what should be done so that it would be even more efficient.
https://medium.com/@dapscience/ai-drug-discovery-grand-challenges-benchmarks-be495dfb5ce4
#compchem #academicChatter #chemistry #medchem #drugDiscovery #drugDevelopment
New Blog Post: Prioritizing Drug-Like 💊 ChEMBL Compounds Within Target 🎯 Profiles
In this post, I go through how to use the #Python #ChEMBL #API and #SQLite to:
• Retrieve compound and target activity data programmatically
• Build a local database of molecules and their associated targets
• Rank compounds based on Lipinski Rule of Five violations
Read it at https://bertiewooster.github.io/2026/01/05/ChEBML-database.html. Marimo and Jupyter notebooks too!
#cheminformatics #drugDiscovery #chemistry #medChem #medicinalChemistry
When reviewing data to find pharma compounds for virtual screening, we might want to check what their target profiles and rank candidates by how many Lipinski’s rule of five violations they have–the fewer the better. Here, a target profile refers to the set of targets a compound is known to be active against. This post uses the ChEMBL API and a SQLite database to do that.
We’re excited to invite you to Computational and Medicinal Chemistry by the Lake 2026, happening June 2–4 in beautiful Kuopio, Finland.
This three-day symposium brings together researchers from academia and industry to explore the latest in drug discovery — from PROTACs to AI-driven screening, molecular dynamics, and more.
We’d love to see you too there — let’s talk science by the lake!
https://sites.uef.fi/cmcl-2026/
#medchem #compchem #science #kuopio #AcademicChatter #drugdiscovery #chemistry
Neue Episode im Wirkstoffradio!
WSR085 Lipidsenker: Statine, Ezetimib und Fibrate mit Hans-Dieter Höltje und Bernd Rupp (@Rupi42ai).
https://www.wirkstoffradio.de/2025/05/04/wsr085-lipidsenker-statine-ezetimib-und-fibrate/
#Lipidsenker #Cholesterol #Statine #Fibrate #Wirkstoffentwicklung #Pharmazie #Biochemie #MedChem
Researchers from #Germany have isolated a novel #antibiotic named saarvienin A. The glycopeptide was obtained from an Amycolatopsis strain by Rolf Müller and his team and was described in the journal Angewandte Chemie. With a completely novel structure, it exhibits excellent antibiotic activity against Gram-positive bacteria and can overcome vancomycin resistance. However, cytotoxicity against eukaryotic cells has also been observed.
Stephan Hacker
Stephan Hacker
GDCh Division of Biochemistry
Piia Bartos
Jeremy Monat
Wirkstoffradio
Chemistry Research