Hey #mdma for #ptsd researchers. CBT and EMDR with and without medicine with #ketamine by mouth as the active placebo. And compare these to sertraline and paroxetine with and without CBT/EMDR then do crossover arms. This is not difficult. #fda #psychedelics #psychedelicresearch #psychedelic #research #cognitivebehavioraltherapy #psychedelicassistedtherapy #psychedelicassistedpsychotherapy #mdmaassistedtherapy #ptsd #cbt #emdr #trauma https://www.fda.gov/media/178984/download
The conceptual framework for the therapeutic approach used in phase 3 trials of MDMA-assisted therapy for PTSD (O'Donnell, et al, 2024) -- https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1427531/full #mdma #mdmaassistedtherapy #mdmaassistedpsychotherapy -- a manualized, trans-theoretical model that assumes that people have a capacity for change #mdma #mdmatherapy #mdmaassistedtherapy #mdmaassistedpsychotherapy #psychotherapy #innerhealingintelligence
Frontiers | The conceptual framework for the therapeutic approach used in phase 3 trials of MDMA-assisted therapy for PTSD

Results from multiple recent studies support further evaluation of 3,4-methylenedioxymethamphetamine (MDMA) in conjunction with psychotherapy (i.e., MDMA-Ass...

Frontiers
#mdma was first legally used in the 1970's and 1980's in psychotherapy and couples therapy where thousands of people were legally dosed within the context of psychedelic-assisted psychotherapy and clinical research showed promising results. #psychedelicassistedpsychotherapy #mdmaassistedtherapy #mdmaassistedpsychotherapy
Health Check: Good golly Miss Molly! Emyria says Ecstasy works for PTSD, months after treatment — Stockhead

Psychedelic drug developer Emyria says the use of MDMA (Molly, or Esstacy) has a lasting effect for post-traumatic stress disorder sufferers.

https://pubmed.ncbi.nlm.nih.gov/39886548/ My Bad, You Got This: witnessing, therapist attitude and the synergy between psychedelics and inner healing intelligence in the treatment of trauma (Fischman, et al, 2025) #mdma #mdmaassistedtherapy #psychedelic #psychedelics #psychedelictherapy #psychedelicassistedpsychotherapy #trauma #mentalhealth #psychedelicmentalhealth
My Bad, You Got This: witnessing, therapist attitude and the synergy between psychedelics and inner healing intelligence in the treatment of trauma - PubMed

The MAPS (Multidisciplinary Association for Psychedelic Studies) sponsored MDMA-assisted therapy protocol has had greater success in treating trauma in preliminary clinical trials than any prior psychotherapeutic, pharmacologic, or combined approach. It is predicated on a synergy between drug action …

PubMed
MDMA and MDMA-Assisted Therapy - PubMed

MDMA (i.e., 3,4-methylenedixoymethamphetamine), commonly known as "Ecstasy" or "Molly," has been used since the 1970s both in recreational and therapeutic settings. The Food and Drug Administration (FDA) designated MDMA-Assisted Therapy (MDMA-AT) as a Breakthrough Therapy for posttraumatic stress di …

PubMed
https://pubmed.ncbi.nlm.nih.gov/39531488/ Cost-effectiveness of midomafetamine-assisted therapy (MDMA-AT) in chronic and treatment-resistant post-traumatic stress disorder of moderate or higher severity: A health-economic model (Stanicic, et al, 2024) #mdma #mdmaassistedtherapy #mdmaassistedpsychotherapy #psychedelic #psychedelics #mentalhealth #psychedelicmentalhealth
Cost-effectiveness of midomafetamine-assisted therapy (MDMA-AT) in chronic and treatment-resistant post-traumatic stress disorder of moderate or higher severity: A health-economic model - PubMed

These data suggest MDMA-AT may be a cost-effective treatment compared to PT for patients with chronic PTSD of moderate or higher severity.

PubMed
What #psychedelics are available for #psychedelicassistedpsychotherapy now that the #fda rejected one company's application for #mdmaassistedtherapy for #ptsd? Generic, racemic #ketamine with many other molecules in various FDA-approved phases of development for many #mentalhealth indications. For use in collaboration with your medical and mental health care providers. https://psychedelicmentalhealth.net/what-medicines-are-available-for-psychedelic-assisted-psychotherapy/
What medicines are available for psychedelic-assisted psychotherapy?

Ketamine is prescribed off-label for several mental health indications, and has been described as psychedelic in the sub-anesthetic mental health and pain management treatment range.

Psychedelic Institute of Mental Health & Family Therapy
With FDA decision looming, bipartisan group of lawmakers urge support for MDMA to treat PTSD

In a show of bipartisanship, 80 members of Congress from both sides of the aisle have united in letters urging President Joe Biden and the US Food and Drug Administration to further consider studies on MDMA-assisted therapy for post-traumatic stress disorder — an effort that aims to expedite access to a treatment they hope could help veterans.

CNN
Experts Endorse MDMA-assisted Therapy for PTSD

Leading researchers and clinicians support the approval of MDMA-assisted therapy for PTSD based on substantial evidence of efficacy and safety from phase 3 clinical trials.